Generic Aspirin Tablets (Acetylsalicylic acid) - Uses, Dosage and Side Effects

Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damaged walls of blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk for developing blood clots. It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue.
Aspirin is a first-line drug in the treatment of migraine, bringing relief in 50-60% of the cases. When used at a high dose of 1000 mg (as compared to 275-325 mg when used as a pain killer or 81 mg as a antiplatelet therapy). no significant differences were seen as compared to triptan medication, sumatriptan (Imitrex) and other painkillers such as paracetamol(acetaminophen) or ibuprofen. Aspirin alleviates pain in 60-75% of patients with episodic tension headaches. It is equivalent to paracetamol (acetaminophen) in that respect, except for the higher frequency of gastrointestinal side effects. Comparative clinical trials indicated metamizole and ibuprofen may relieve pain faster than aspirin, although the difference becomes insignificant after about two hours. The addition of caffeine in a dose of 60-130 mg to aspirin increases the analgesic effect in headache. The combination of aspirin, paracetamol (acetaminophen) and caffeine (Excedrin) is still more effective, but at the cost of more stomach discomfort, nervousness and dizziness.
There are two distinct uses of aspirin for prophylaxis of cardiovascular events: primary prevention and secondary prevention. Primary prevention is about decreasing strokes and heart attacks in the general population of those who have no diagnosed heart or vascular problems. Secondary prevention concerns patients with known cardiovascular disease.[33] Low doses of aspirin are recommended for the secondary prevention of strokes and heart attacks. For both males and females diagnosed with cardiovascular disease, aspirin reduces the chance of a heart attack and ischaemic stroke by about a fifth.
Although aspirin has been used to combat fever and pains associated with common cold for more than 100 years, only recently its efficacy was confirmed in controlled clinical trials on adults. One gram of aspirin, on average, reduced the oral body temperature from 39.0 °C (102.2 °F) to 37.6 °C (99.7 °F) after three hours. The relief began after 30 minutes, and after six hours, the temperature still remained below 37.8 °C (100.0 °F). Aspirin also helped with "achiness", discomfort and headache, and with sore throat pain, for those who had it. Aspirin was indistinguishable from paracetamol in any respect, except for, possibly, slightly higher rate of sweating and gastrointestinal side effects.


Side Effects of Generic Aspirin Tablets (Acetylsalicylic acid)

The main side effects of aspirin are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. In children and adolescents, aspirin is no longer used to control flu-like symptoms or the symptoms of chickenpox or other viral illnesses, because of the risk of Reye's syndrome.
Reye's syndrome, a rare but severe illness characterized by acute encephalopathy and fatty liver, can occur when children or adolescents are given aspirin for a fever or other illnesses or infections. 93% of those reported with Reye's syndrome reported being ill in the three weeks preceding onset of Reye's syndrome, most commonly with a respiratory infection, chickenpox, or diarrhea. Aspirin can cause prolonged bleeding after operations for up to 10 days.

Generic Aspirin Tablets (Acetylsalicylic acid) - Dosage

For adults, doses are generally taken four times a day for fever or arthritis, with doses near the maximal daily dose used historically for the treatment of rheumatic fever. For the prevention of myocardial infarction in someone with documented or suspected coronary artery disease, much lower doses are taken once daily.
For a small number of people, taking aspirin can result in symptoms that resemble an allergic reaction, including hives, swelling and headache. The reaction is caused by salicylate intolerance and is not a true allergy, but rather an inability to metabolize even small amounts of aspirin, resulting in an overdose. Each dose of Aspirin tablets should usually be taken with a glass of water unless patient is fluid restricted. Usual doses for mild to moderate pain are 325 mg every 4 hours,Doses for rheumatoid arthritis include 325 mg every 4-6 hours, Heart attacks are prevented with 75, 150 or 325 mg daily.

Contraindications Of Generic Aspirin Tablets (Acetylsalicylic acid)

Aspirin should not be taken by people who are allergic to ibuprofen or naproxen, or who have salicylate intolerance or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID-precipitated bronchospasm. Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using aspirin. The United States Food and Drug Administration now recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever, and the British Medicines and Healthcare products Regulatory Agency (MHRA) recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor.

Generic Aspirin Tablets (Acetylsalicylic acid) - Availability And Packaging

Acetylsalicylic Acid Tablets is available as Generic Aspirin Tablets which is packaged in 75 mg, 150 mg and 325 mg.

Additional Information

Prescribing Information

Considerable portions of the text here is from and is reproduced here under the Creative Commons Attribution-ShareAlike License