Amlodipine - Generic Names, Uses, Dosage and Amlodipine Side Effects

Amlodipine is a long-acting calcium channel blocker in the dihydropyridine class which is used as an anti-hypertensive and in the treatment of angina. Similar to other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall which in turn decreases the total peripheral resistance and hence reduces the blood pressure. In angina it increases blood flow to the heart muscle.
Pfizer was the patent holder on Amlodipine and manufactured it under the Norvasc brand name. Upon patent expiration in 2007, a number of generic versions are available from several manufacturers.


Amlodipine is used in the treatment of Hypertension as well as Angina pectoris.

Amlodipine - Contraindications

It is inadvisable to use this drug in case of a person having cardiogenic shock, unstable angina, aortic stenosis and during breast feeding. Amlodipine causes vasodilatation, which in patients with severe aortic stenosis, can result in reduced cardiac output.
There is not absolute consensus about the contraindication, because if the patient has hypertension, his stenosis cannot be very severe, otherwise he would not have sufficient output to allow hypertension.
Precautions are to be taken in case of patients who are pregnant or have hepatic impairment. Please consult your doctor in all cases.

Side effects of Amlodipine

Some side effects of the use of amlodipine are mentioned below along with the frequency of occurence. Side effects that occur very often include peripheral edema of feet and ankles reportedly in 1 of 10 users.
Other side effects include dizziness; palpitations; muscle , stomach or headache; dyspepsia; nausea which occur frequently in about 1 in 100 users
The less frequently occuring side effects include blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia and Gingival overgrowth which occur in 1 in 1,000 users.
The Rarely occuring include erratic behavior, hepatitis, jaundice which occur in 1 in 10,000 users. Hyperglycemia, tremor, Stevens-Johnson syndrome occur very rarely, reportedly in just 1 person for every 100,000 users.

Amlodipine Dosage

The dosage for Hypertension or angina is 2.5 to 10 mg once daily. During the initial treatment the dose can start as low as 2.5 mg per day, titrate up to 10 mg/day as necessary.

Availability And Packaging

Amlodipine is available in the form of Generic Norvasc Tablets in 5mg and 10mg tablets. Amlodipine is also available in several other generic versions like Amlopres Pills in 5mg and 10mg pills. It is also available in the form of Stamlo Tablets in 5mg and 10mg.

Generic Versions And Brand names of Amlodipine

Amlodipine is marketed as Norvasc, Perivasc, Istin, Agen, Amdipin, Amlodine, Amdepin, Dailyvasc, Lopin, Amlopine, Amcard and Amlopres. It is also marketed as Hipril which is a combination of 5mg lisinopril with 5mg amlodipine.

Additional Information

Manufacturers pamphlet: Pfizer - Prescribing information for US residents

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