Buspirone Hydrochloride (Generic Buspar Tablets) - Product information and Uses

Buspirone hydrochloride is an antianxiety agent. Buspirone is used primarily as an anxiolytic, specifically for generalized anxiety disorder.
Buspar (Buspirone) is supplied as tablets for oral administration containing 5 mg, 10 mg, 15 mg, or 30 mg of buspirone hydrochloride which is equivalent to 4.6 mg, 9.1 mg, 13.7 mg, and 27.4 mg of buspirone free base, respectively.

Buspirone Hydrochloride (Generic Buspar) - Availability And Packaging

Buspirone Hydrochloride is available as Generic Buspar Tablets (Buspin) which is packaged in 10 mg pills.

Uses of Buspirone Hydrochloride (Generic Buspar)

Generic Buspar is used to treat the following indications:
Generalized anxiety disorder (GAD) of very mild to moderate intensity, without any panic attacks (it is not generally considered to be effective, nor does it have regulatory approval for other types of anxiety disorders such as obsessive-compulsive disorder (OCD) and social phobia, with or without agoraphobia).
Although not FDA approved for the indication, it is sometimes used off-label for augmentation of selective serotonin reuptake inhibitor (SSRI) therapy against depression.

Buspirone Hydrochloride (Generic Buspar) - Contraindications

Buspirone (Generic Buspar) is contraindicated in the following cases:

  • Hypersensitivity to Buspirone Hydrochloride or any inactive component of the medication.
  • Acute, closed-angle glaucoma
  • Asthma, history of bronchiospasm or obstructive airways disease
  • Epilepsy
  • Pre-existing heart conditions (e.g., myocardial infarction)
  • Severely compromised liver and/or renal function
  • Metabolic acidosis, as in diabetes
  • Myasthenia gravis

Buspirone Hydrochloride (Generic Buspar) - Interactions

Listed below are the interactions of  Buspirone Hydrochloride:

  • Carbamazepine: Increased plasma levels of buspirone.
  • Grapefruit, grapefruit juice, significantly increases the plasma levels of buspirone.[10] The probable mechanism of this interaction is delayed gastric emptying and inhibition of the cytochrome P450 3A4-mediated first-pass metabolism of buspirone caused by grapefruit juice.
  • Haloperidol: Increased plasma levels of buspirone.
  • Rifampicin: Decreased plasma levels of buspirone.

Side Effects of Buspirone Hydrochloride (Generic Buspar)

Commonly occuring side Effects of Buspirone Hydrochloride (Generic Buspar) include dizziness, nausea, headache, nervousness, lightheadedness, and excitement.

Buspirone Hydrochloride (Generic Buspar) - Dosage

The recommended initial dose of Generic Buspar is 15 mg daily (7.5 mg twice a day). For attaining an optimal therapeutic response, the dosage may be increased by 5 mg per day, at intervals of 2 to 3 days. The maximum daily dosage should not exceed 60 mg per day.

Additional Information

Additional Info: Prescribing Information

Considerable portions of the text here is from http://en.wikipedia.org/wiki/Buspirone and is reproduced here under the Creative Commons Attribution-ShareAlike License