Clomiphene Citrate - Product information and Uses

Clomiphene Citrate or Clomiphene or Clomid or Fertomid or Clomifert is a selective estrogen receptor modulator (SERM) that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. It is used mainly in female infertility, in turn mainly as ovarian stimulation to reverse oligoovulation or anovulation such as in infertility in polycystic ovary syndrome, as well as being used for ovarian hyperstimulation, such as part of an in vitro fertilization procedure.
clomifene is given early in the menstrual cycle. It is typically prescribed beginning on day 1, 3 or 5 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. In the presence of clomifene, the body perceives a low level of estrogen, similar to day 22 in the previous cycle. Since estrogen can no longer effectively exert negative feedback on the hypothalamus, GnRH secretion becomes more rapidly pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release.
Increased FSH level causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation.

Clomiphene Citrate - Availability And Packaging

Clomiphene Citrate is available as Fertomid (Generic Clomid) which is packaged in 25 mg and 50 mg tablets. Clomifene citrate is marketed under various trade names including Fertomid, Clomid, Serophene, Milophene and Clomifert.

Side Effects of Clomiphene Citrate

Common adverse drug reactions associated with the use of clomifene in greater than or equal to 1% of patients include vasomotor flushes (or hot flashes ), abdominal discomfort, visual blurring (dose-dependent), and/or reversible ovarian enlargement and cyst formation. Infrequent adverse effects include: abnormal uterine bleeding, nausea, and/or vomiting. Rare adverse effects that occur in less than 0.1% of patients include: reversible alopecia and/or ovarian hyperstimulation syndrome.
Clomifene (Generic Clomid) can lead to multiple ovulation, hence increasing the chance of twins (10% of births instead of the normal ~1%). In comparison to treatment with purified FSH, the rate of ovarian hyperstimulation syndrome is low.

Clomiphene Citrate (Generic Clomid) - Dosage

The recommended dose of Clomiphene (Generic Clomid) is 50 mg daily (1 tablet) for 5 days. The dose of Generic Clomid should be increased only in those patients who do not ovulate in response to cyclic 50 mg Clomiphene.

Overdosage and Overdose Symptoms of Clomiphene Citrate

Toxic effects accompanying acute overdosage of Clomiphene have not been reported.
Signs and symptoms of overdosage as a result of the use of more than the recommended dose during Generic Clomid therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Clomifene