Clopidogrel Bisulfate (Generic Plavix) - Uses, Dosage and Side Effects

Clopidogrel is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
Clopidogrel Bisulfate is used for Prevention of vascular ischemic events in patients with symptomatic atherosclerosis, Acute coronary syndrome without ST-segment elevation (NSTEMI)and ST elevation MI (STEMI). Generic Plavix is also used, along with aspirin, for the prevention of thrombosis after placement of intracoronary stent or as an alternative antiplatelet drug for patients who are intolerant to aspirin

Side Effects of Clopidogrel Bisulfate (Generic Plavix)

Serious side effects associated with Clopidogrel Bisulfate (Generic Plavix) therapy include Severe neutropenia (low white blood cells), Thrombotic thrombocytopenic purpura (TTP) Gastrointestinal Hemorrhage, Cerebral Hemorrhage. Other serious side effects of Generic Plavix include skin irritations, respiratory difficulties, bloody stools and vomit, bloating of facial features, limbs and joints, exhaustion etc.

Warnings and Precautions when Using Generic Plavix Tablets (Clopidogrel Bisulfate)

The annual incidence of hemorrhage may be increased by the co-administration of aspirin. Use of non-steroidal anti-inflammatory drugs is discouraged in those taking clopidogrel due to increased risk of digestive tract hemorrhage

Clopidogrel Bisulfate (Generic Plavix) - Contraindications

Clopidogrel therapy is contraindicated in persons that have hypersensitivity to clopidogrel or any component of the product. Generic Plavix is also contraindicated in patients that have active pathological bleeding, such as peptic ulcer or intracranial hemorrhage.

Clopidogrel Bisulfate (Generic Plavix) - Dosage

The dosing for Generic Plavix is as follows

Acute coronary syndrome
- Non-ST-segment elevation ACS (UA/NSTEMI): 300 mg loading dose followed by 75 mg once daily, in combination with aspirin (75-325 mg once daily)
- STEMI: 75 mg once daily, in combination with aspirin (75-325 mg once daily), with or without a loading dose and with or without thrombolytics
Recent MI, recent stroke, or established peripheral arterial disease: 75 mg once daily

Clopidogrel Bisulfate - Availability And Packaging

Clopidogrel is available as Generic Plavix Tablets, Plagril manufactured by Dr. Reddy's Pharmaceuticals which is packaged as 75 mg oral tablets.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Clopidogrel and is reproduced here under the Creative Commons Attribution-ShareAlike License