Estriol Vaginal Cream (Generic Ovestin) - Product information and Uses

Generic Ovestin Cream is used in Hormone Replacement Therapy (HRT) in women. It contains Estriol. Estriol (also known as oestriol) is one of the three main female hormones, called oestrogens, produced by the human body. During and after menopause the oestrogen production by the body decreases. The decrease in Estriol production may lead to hot flushes, vaginal irritation, recurrent urinary tract infections and urinary incontinence. Generic Ovestin Cream is usually prescribed for the loss of oestrogen production by the body. After Estriol Vaginal Cream is inserted into the vagina, oestriol is slowly released and absorbed into the surrounding area and even into the bloodstream.
Estriol Vaginal Cream substitutes for the loss of oestrogen production in menopausal women and alleviates menopausal symptoms. Oestriol is particularly effective in the treatment of urogenital symptoms such as dyspareunia, dryness, itching, vaginal and urinary infections, micturition complaints and mild urinary incontinence.

Generic Ovestin Cream - Availability And Packaging

Generic Ovestin Cream is available as Estriol Vaginal Cream (Evalon Vaginal Cream) which is packaged in tubes of 15 grams.

Side Effects of Estriol Vaginal Cream (Generic Ovestin)

Estriol Vaginal Cream, like most other medications, can also cause side effects. Generic Ovestin may occasionally cause side effects that are dependent on dosage and the sensitivity of the individual patient. The most common side effects include local irritation or itching, swelling and increased tenderness of the breasts. In most patients these side effects will disappear after the first weeks of treatment. Inform you doctor immediately if vaginal bleeding occurs, or if any side effect becomes troublesome or continues.
Other side-effects which may occur with Hormone Replacement Therapy (HRT) are: Benign and malignant hormone-dependent tumours such as breast cancer and endometrial cancer, venous thromboembolism or deep leg or pelvic venous thrombosis and pulmonary embolism , heart attack and stroke, gall bladder disease, skin problems such as rashes, discolouration or red patches on the skin various skin diseases with blisters and nodules or bleeding into the skin. Using HRT for several years slightly increases the risk of breast cancer and dementia .


Overdosage occurrence with Generic Ovestin cream after vaginal administration is unlikely. In cases where where large quantities are ingested, nausea, vomiting and withdrawal bleeding in females may occur. Symptomatic treatment can be given if necessary.


Estriol Vaginal Cream (Generic Ovestin) is contraindicated in individuals that:

  • Are pregnant
  • Known, past or suspected breast cancer
  • Known or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer)
  • Undiagnosed genital bleeding
  • Untreated endometrial hyperplasia
  • Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)
  • Known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency)
  • Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction)
  • Acute liver disease, or a history of liver disease as long as liver function tests failed to return to normal
  • Known hypersensitivity to the Estriol or to any other ingredients present in Generic Ovestin
  • Porphyria

Estriol Vaginal Cream - Dosage

The normally recommended dosage is 1 application of Estriol Vaginal Cream per day for the first weeks, followed by a gradual reduction, based on relief of symptoms, until a maintenance dosage (e.g. 1 application twice a week) is reached.

Additional Information

Additional Info: Prescribing Information