Fluconazole (Generic Diflucan) - Product information and Uses

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Fluconazole appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol. It is commonly marketed under the trade name Diflucan, Forcan, Trican, Alfumet, Afungil or Dofil.
Like other imidazole- and triazole-class antifungals, fluconazole inhibits the fungal cytochrome P450 enzyme 14a-demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol. Fluconazole is primarily fungistatic; however, it may be fungicidal against certain organisms in a dose-dependent manner.
Fluconazole is active against the following microorganisms:Blastomyces dermatitidis,Candida spp. (except C. krusei and C. glabrata), Coccidioides immitis, Cryptococcus neoformans, Epidermophyton spp., Histoplasma capsulatum, Microsporum spp. and Trichophyton spp.
Fluconazole is a drug indicated for the treatment and prophylaxis of fungal infections where other antifungals have failed or are not tolerated (for example due to adverse effects), including Candidiasis caused by susceptible strains of Candida , Tinea corporis, tinea cruris or tinea pedis, Onychomycosis, Cryptococcal meningitis. Fluconazole can be used first-line for the following indications: Coccidioidomycosis, Cryptococcosis, Histoplasmosis, Prophylaxis of candidiasis in immunocompromised people.

Fluconazole - Availability And Packaging

Fluconazole is available as Generic Diflucan Tablets which is packaged in 150 mg and 200 mg tablets.

Fluconazole (Generic Diflucan) - Dosage

Fluconazole should nver be used by anyone below the age of eighteen. The reason being that Generic Diflucan can cause many problems to the abdomen on a younger child. Dosage varies with indication and between patient groups, ranging from: a two-week course of 150 mg/day for vulvovaginal candidiasis, to 150-300 mg once weekly for resistant skin infections or some prophylactic indications. A dosage of 500-600 mg/day may be used for systemic or severe infections.
A loading dose will be indicated when entering a daily dosage schedule; for example, a loading dose of 200 mg on the first day is commonly used with 150 mg/day following that.

Fluconazole (Generic Diflucan) - Contraindications

Fluconazole is contraindicated in patients that:
1)Have known hypersensitivity to Fluconazole or other azole medicine
2)Are taking terfenadine, if 400 mg per day multidose of fluconazole is administered
3)Concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high dosages
4)Are pregnant.

Side Effects of Fluconazole (Generic Diflucan)

Common Side effects that occur in 1% or more patients associated with fluconazole therapy include rash, headache, dizziness, nausea, vomiting, abdominal pain, diarrhea, and/or elevated liver enzymes.
Infrequent adverse effects include anorexia, fatigue, constipation . Rare side effects include oliguria, hypokalaemia, paraesthesia, seizures, alopecia, Stevens-Johnson syndrome, thrombocytopenia, other blood dyscrasias, serious hepatotoxicity including hepatic failure, anaphylactic/anaphylactoid reactions. Very rare adverse effects are prolonged QT interval, torsades de pointes

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Fluconazole and is reproduced here under the Creative Commons Attribution-ShareAlike License