Fluorouracil (Generic Carac Cream) - Product information and Uses

Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin.
The chemotherapy agent Fluorouracil, which has been in use against cancer, acts in several ways, but principally as a thymidylate synthase inhibitor. Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidine, which is a nucleotide required for DNA replication.
Like many anti-cancer drugs, Fluorouracil effects are felt system wide but fall most heavily upon rapidly dividing cells that make heavy use of their nucleotide synthesis machinery, such as cancer cells (other parts of the body with rapidly dividing cells include the cells lining the digestive tract).
Fluorouracil can be used topically as a cream for treating actinic (solar) keratoses and some types of basal cell carcinomas of the skin. It is often referred to by its trade names Flonida, Efudex, Carac or Fluoroplex.

Fluorouracil (Generic Carac Cream) - Availability And Packaging

Fluorouracil is available as Generic Carac Cream which is packaged in 10g tubes of 1% and 5% concentrations. It is also available under the brand names Flonida cream, Adrucil, Efudix, Efudex and Fluoroplex.

Side Effects of Fluorouracil (Generic Carac Cream)

Side effects include myelosuppression, mucositis, dermatitis, diarrhea and cardiac toxicity.
Fluorouracil injection and topical even in small doses cause both acute CNS damage and progressively worsening delayed degeneration of the CNS in mice. This latter effect is caused by Fluorouracil induced damage to the oligodendrocytes that produce the insulating myelin sheaths.

Fluorouracil (Generic Carac Cream) - Dosage

The patient should be instructed to apply sufficient medication to cover the entire face or other affected areas. Apply medication twice daily with fingertips and wash hands afterwards. A treatment period of 2-6 weeks is usually required.

Additional Information

Additional Info: Prescribing Information