Fluvoxamine Uses, Dosage and Side Effects

Fluvoxamine which is marketed under the brand name Luvox, is an antidepressant which functions as a selective serotonin reuptake inhibitor (SSRI). Fluvoxamine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of obsessive compulsive disorder (OCD).
Fluvoxamine CR (controlled release) is approved to treat social anxiety disorder. Fluvoxamine is also prescribed to treat major depression and anxiety disorders, such as obsessive compulsive disorder (OCD), generalized anxiety disorder (GAD), panic disorder, and post-traumatic stress disorder. Fluvoxamine is widely prescribed to treat major depressive disorder, and anxiety disorders such as , generalized anxiety disorder (GAD), panic disorder, social phobia, and post-traumatic stress disorder (PTSD).

Luvox TabletsView Of Luvox Tablets

Fluvoxamine - Contraindications

Fluvoxamine has a low potential for the drug interactions which are based on inhibition of enzyme Cytochrome P450 CYP2D6. Fluvoxamine shows the least interaction of the SSRIs, in regard to this specific enzyme.
Fluvoxamine does, however, inhibit cytochrome P450 enzyme CYP1A2, which metabolises agomelatine, caffeine, clozapine, haloperidol, phenacetin, tacrine, theophylline, and olanzapine. These substances can cause increased serum levels when administered together with fluvoxamine. Smokers may require significant modification of medication dosage as the polycyclic aromatic hydrocarbons found in tobacco smoke are potent inducers of CYP1A2.
Fluvoxamine inhibits metabolism of diazepam and phenytoin via CYP2C19 and metabolism of aripiprazole, chlorpromazine, clozapine, haloperidol, olanzapine, perphenazine, risperidone, thioridazine and zuclopenthixol via CYP2D6 as well as of aripiprazole, clozapine, haloperidol, quetiapine, risperidone and ziprasidone via CYP3A4.

Side effects of Fluvoxamine

Various side effects have been noted in patients using
Side effects most commonly observed with fluvoxamine include nausea, vomiting, drowsiness, difficulty sleeping, dizziness, nervousness, feeling anxious, dry mouth, abdominal pain, constipation, diarrhea, heart burn, loss of appetite, muscle weakness, pins and needles, abnormal taste, headache, faster heart beat, sweating, weight gain, weight loss or unusual bruising. Other side effects which are observed more frequently in children include abnormal thoughts or behaviour, cough, increased period pain, nose bleeds, increased restlessness, infection and sinusitis.

Fluvoxamine Dosage

Below is the recommended Fluvoxamine dosage for in the form of Luvox tablets.Adults: Recommended starting dose is 50 mg at bedtime, with increases of 50 mg every 4 to 7 days as tolerated to maximum effect, not to exceed 300 mg/day Daily doses over 100mg should be divided.
Children and adolescents (8-17 years): Recommended starting dose is 25 mg at bedtime, with increases of 25 mg every 4 to 7 days as tolerated to maximum effect, not to exceed 200 mg/day (8-11 years) or 300 mg/day (12-17 years). Daily doses over 50mg should be divided .
Hepatically impaired: Decreased clearance may require modified dose.
For extended treatment the dose has to be adjusted inorder to maintain lowest effective dose and patients have to be reassessed periodically .

Availability And Packaging

Fluvoxamine is available as Generic Luvox Tablets in 50 mg and 100 mg.

Additional Information

Manufacturers pamphlet: Prescribing information

Considerable portions of the text here is from http://en.wikipedia.org/wiki/Fluvoxamine and is reproduced here under the Creative Commons Attribution-ShareAlike License