Isotretinoin (Generic Accutane) - Product information and Uses

Isotretinoin, is a medication used mostly for cystic acne, however, it is also employed for a number of cancers and a few severe skin conditions. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer, and other cancers and is still used in the treatment of these cancers because of its ability to kill rapidly dividing cells.
It is a retinoid, meaning it derives from vitamin A, and is found in small quantities naturally in the body. Isotretinoin's most well-known side effect is that it acts as a severe teratogen. This is related to the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development. It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea.
It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer. Isotretinoin's main indication is for the treatment of severe cystic acne vulgaris. Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.

Isotretinoin - Availability And Packaging

Isotretinoin is available as Generic Accutane which is packaged in 10 and 20 mg capsules.
Oral Isotretinoin is marketed under many brand names by various manufacturers. Some brands of oral isotretinoin include Isotroin (Cipla), Accure (Alphapharm), Accutane and Roaccutane (Roche), Aknenormin (Hermal), Amnesteem (Mylan), Ciscutan (Pelpharma), Claravis (Barr), Clarus (Prepharm), Isohexal (Hexal Australia), Istretinoin-A (Pharmathen), Isosupra (SMB Laboratories), Isotane (Pacific Pharmaceuticals),Oratane (Douglas Pharmaceuticals), Atretin (Lafrancol), Nimegen (Medica Korea) , Acnotin (Mega Lifesciences) , Ruatine (United Pharmaceutical)and Sotret (Ranbaxy). Topical isotretinoin is most commonly marketed under the trade names Isotrex or Isotrexin (Stiefel).

Side Effects of Isotretinoin (Generic Accutane)

Increasingly higher dosages of Generic Accutane will result in higher toxicity, resembling vitamin A toxicity. The undesirable side effects and drug reactions associated with isotretinoin therapy include: Common Side Effects: Extreme severe acne flare, dryness of skin, lips and mucous membranes, infection of the cuticles, cheilitis, itch, rosacea, skin fragility, skin peeling, rash, flushing, nose bleeds, dry eyes, diffuse alopecia areata, eye irritation, conjunctivitis, reduced tolerance to contact lenses, hyperlipidaemia, raised liver enzymes, permanent thin skin, headaches, temporary or permanent hair thinning (this could start or continue after treatment), myalgia and/or arthralgia, back pain and hyperhidrosis.
Infrequent Side Effects: mild acne flare, raised blood glucose level, decreased libido or erectile dysfunction, increased erythrocyte sedimentation rate, and fatigue
Rare Side Effects: impaired night vision, cataracts, optic neuritis, menstrual disturbances, inflammatory bowel disease, pancreatitis, hepatitis, corneal opacities, papilloedema, idiopathic intracranial hypertension, skeletal hyperostosis, extraosseous calcification, psychosis, and depression
The following adverse effects have been reported to persist in some patients for whom they occurred even after discontinuing therapy: alopecia (hair loss), arthralgias (joint pain), decreased night vision, inflammatory bowel disease, degenerative disc disease, keloids, osteopenia, hyperlipidemia, erectile dysfunction, psychiatric disturbances, dry eyes, and "dry skin".

Isotretinoin (Generic Accutane) - Dosage

Accutane should be administered with a meal. The recommended dosage range for Accutane is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks.

Additional Information

Additional Info: Prescribing Information



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