Generic Vagifem Pessaries - Product information and Uses

Estradiol is a sex hormone. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary.
When used for menopausal hormone replacement therapy, vaginally administered estrogens are intended to decrease the uncomfortable effects on the vagina, vulva and urethra that are caused by the decrease in estrogen production in the body after menopause. Vaginally administered estrogens are estrogens that are delivered by intravaginal administration, thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens.
Vagifem is a modified release pessary used to treat discomfort of the vagina. Vagifem is used for the treatment of certain vaginal symptoms which occur after menopause, such as dryness, itchiness and pain during sexual intercourse.
This is caused by a drop in the level of a hormone called oestrogen. Women have a decreased level of this hormone after menopause. Oestradiol which is in Vagifem is a natural type of oestrogen.

Vaginally administered Estradiol - Availability And Packaging

Vaginally administered estrogens like Estradiol is available as Generic Vagifem Pessaries which is packaged in 2 mg Pessaries. Generic Vagifem Pessary is also referred to as Vagifem Suppository, Estradiol, Estrace, Estring, Femring and Estring Ring.

Side Effects of Generic Vagifem Pessaries

The commonly occuring Side Effects of Generic Vagifem Pessaries were upper respiratory tract infection, headache, abdominal pain, back pain, genital pruritis, moniliasis, vulvovaginal mycotic infection and diarrhea

Generic Vagifem Pessaries - Dosage

Vagifem should be administered intravaginally. The dosage is 1 tablet daily for 2 weeks, followed by 1 tablet twice weekly.

Generic Vagifem Pessaries - Contraindications

Generic Vagifem Pessaries is contraindicated in patients that have:
Undiagnosed abnormal genital bleeding
Known, suspected, or history of breast cancer
Known or suspected estrogen-dependent neoplasia
Active deep vein thrombosis, pulmonary embolism or history of these conditions
Active arterial thromboembolic disease (for example, stroke and myocardial infarction or a history of these conditions
Known liver dysfunction or disease
Known or suspected pregnancy

Generic Vagifem Pessaries - Overdose

Overdosage of estrogen may cause nausea and vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue and withdrawal bleeding in women. Treatment of overdose consists of discontinuation of Vagifem together with institution of appropriate symptomatic care.