Hyoscine Butylbromide also known as Butylscopolamine, scopolamine butylbromide and butylhyoscine is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and paracetamol, marketed under the name Buscopan Plus.
Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood-brain barrier, effectively minimising undesirable CNS side-effects associated with scopolamine/hyoscine.
Hyoscine Butylbromide is available as Buscopan Tablets which is packaged in 10 mg tablets.
Listed below are the side effects of Buscopan tablets:
Xerostomia (dry mouth), dyshidrosis, visual accomodation disorders, tachycardia, dyspnea, and urinary retention.There have been rare reports of dizziness, blood pressure decreased and flushing. Skin reactions and other hypersensitivity, angioedema and fixed drug eruptions have been reported rarely.
There have been very rare reports of anaphylactic reactions and anaphylactic shock including fatal outcome. Adverse events reported during therapy with Buscopan include increased pulse rate, diarrhea, nausea, retinal pigmentation, and glaucoma.
The recommended adult dosage of Buscopan is One to two 10 mg tablets per day up to a maximum of 6 tablets per day. In prolonged illness which requires repeated dosing, 1 tablet 3 to 5 times a day is recommended.
Individual response to Buscopan (Hyoscine Butylbromide) may vary and doses should be adjusted accordingly.
Hypersensitivity to hyoscine butylbromide, or atropinics or to any of the product inactive ingredients. Buscopan (hyoscine butylbromide) tablets are contraindicated in patients with myasthenia gravis, megacolon, glaucoma or obstructive prostatic hypertrophy.
Parenteral administration is contraindicated in patients with myasthenia gravis, untreated narrow angle glaucoma, prostatic hypertrophy with urinary retention, stenotic lesions of the gastrointestinal tract, tachycardia, angina, cardiac failure and megacolon.
Additional Info: Prescribing Information