Ibuprofen Uses, Dosage and Side Effects

Ibuprofen is a non-steroidal anti-inflammatory drug marketed as Brufen, andalso under various other brand names such as Nurofen, Advil, and Motrin.
It is used for relief of symptoms of arthritis, primary dysmenorrhea, fever, and as an analgesic, specially where there is an inflammatory component. Ibuprofen is known to have an antiplatelet effect, which relatively mild and short-lived when compared with that of aspirin and other better-known antiplatelet drugs. Ibuprofen also generally acts as a vasodilator, having been shown to dilate coronary arteries and some other blood vessels.

Ibuprofen TabletsView Of Generic Ibuprofen Tablets

Ibuprofen - Contraindications

Cardiovascular Risk:
Ibuprofen has been implicated in elevating the risk of myocardial infarction (heart attack), particularly among those chronically using high doses.
Risks in inflammatory bowel disease (IBD)
Ibuprofen should not be used regularly in individuals with inflammatory bowel disease due to its ability to cause gastric bleeding and form ulceration in the gastric lining. Pain relievers such as paracetemol/acetaminophen or drugs containing codeine (which slows down bowel activity) are safer methods than ibuprofen for pain relief from IBD. Ibuprofen is also known to cause worsening of IBD during flare-ups, so it should be avoided completely at those times.

Side effects of Ibuprofen

Various side effects have been noted in patients using Ibuprofen. Common adverse effects of Ibuprofen include nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, constipation, epistaxis, headache, dizziness, priapism, rash, salt and fluid retention, and hypertension.
Infrequent adverse effects include: esophageal ulceration, heart failure, hyperkalemia, renal impairment, confusion, and bronchospasm. Ibuprofen appears to have the lowest incidence of digestive adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ibuprofen, so over-the-counter preparations of ibuprofen are generally labeled to advise a maximum daily dose of 1,200 mg.

Ibuprofen Dosage

Usually the oral dose is 200–400 mg (5–10 mg/kg in children) every 4–6 hours, adding up to a usual daily dose of 800–1,200 mg. The maximum daily dose for over-the-counter use is 1,200 mg. under medical direction however the maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses).

Availability And Packaging

Ibuprofen is commonly available in 200 mg doses for over the counter use. Higher doses are only available in the US by prescription. In Canada and several other countries 300 mg and 400 mg doses are available over the counter as Motrin Tablets.

Additional Information

Manufacturers pamphlet:

Considerable portions of the text here is from http://en.wikipedia.org/wiki/Ibuprofen and is reproduced here under the Creative Commons Attribution-ShareAlike License