Imipramine Hydrochloride (Tofranil) - Uses, Dosage and Side Effects

Imipramine Hydrochloride, also known as melipramine, is an antidepressant medication. Imipramine is mainly used in the treatment of major depression and enuresis (inability to control urination). As an antidepressant, Imipramine Hydrochloride is known to work well in even the most severe cases of depression.
Generic Tofranil (Imipramine Hydrochloride) has limited use in the treatment of migraines, ADHD, and post concussive syndrome. Imipramine has additional indications for the treatment of panic attacks, chronic pain, and Kleine-Levin syndrome. In pediatric patients, it is relatively frequently used to treat pavor nocturnus and nocturnal enuresis.

Imipramine Hydrochloride - Availability And Packaging

Imipramine Hydrochloride is available as Generic Tofranil Tablets which is packaged in 25 mg and 75 mg tablets. Generic Tofranil (Imipramine Hydrochloride) is also sold as Antideprin, Deprimin, Deprinol, Depsol, Depsonil, Dynaprin, Eupramin, Imipramil, Irmin, Janimine, Melipramin and Surplix

Side Effects of Imipramine Hydrochloride (Tofranil)

The side effects of Generic Tofranil tablets (Imipramine Hydrochloride) are

  • Central Nervous System: Dizziness, drowsiness, confusion, seizures, headache, anxiety, tremors, stimulation, weakness, insomnia, nightmares, Extrapyramidal symptoms in geriatric patients, increased psychiatric symptoms, paresthesia
  • Cardiovascular: Orthostatic hypotension, EKG changes, tachycardia, hypertension, palpitations, dysrhythmias
  • Eyes, Ears, Nose and Throat: Blurred vision, tinnitus, mydriasis
  • Gastrointestinal: Diarrhea, Dry mouth, nausea, vomiting, paralytic ileus, increased appetite, cramps, epigastric distress, jaundice, hepatitis, stomatitis, constipation, taste change
  • Genitourinary: Urinary retention, acute renal failure
  • Hematological: Agranulocytosis, thrombocytopenia, eosinophilia, leukopenia
  • Skin: Rash, urticaria, sweating, pruritus, photosensitivity


Imipramine Hydrochloride (Tofranil) - Dosage

The adult Dosage for Imipramine Hydrochloride (Tofranil)is as follows:

  • Hospitalized patients: starting with 3 times 25 mg, increasing to 125 mg. Up to 300 mg may be given in resistant cases. After remission dose is often reduced to 50 to 100 mg daily.
  • Ambulatory patients: starting with 25 to 75 mg daily, increasing up to a maximum of 200 mg daily, after remission dose is often reduced to 50-100 mg daily.
  • Pediatric patients: starting with 10 mg daily the dose is adjusted according to the severity of the symptoms to be treated, the side-effects encountered and the weight of the patient.


Overdosage and Overdose Symptoms of Imipramine Hydrochloride (Tofranil)

The symptoms and the treatment of an overdose are largely the same as for the other tricyclic antidepressants. Cardinal symptoms are cardiac (tachycardia, widened QRS complex) and neurological disturbances. Any ingestion by children should be considered as serious and potentially fatal.

Additional Information

Additional Info: Prescribing Information

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