Imiquimod Cream (Aldara or Imiquad Cream) - Uses, Dosage and Side Effects

Imiquimod is a patient-applied cream used to treat certain diseases of the skin, including skin cancers (basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis) as well as External genital and perianal warts/condyloma acuminata in patients 12 years old or older. It has also been tested for treatment of molluscum contagiosum, vulvar intraepithelial neoplasia, common warts that have proven difficult to treat, and vaginal intraepithelial neoplasia. Outstanding cosmetic result has resulted from the treatment of both large superficial basal cell carcinoma and squamous cell carcinoma in-situ, but the morbidity and discomfort of the treatment can be severe.
The original FDA approval was on February 27, 1997. Imiquimod is approved to treat actinic keratosis, superficial basal cell carcinoma, and external genital warts. Adverse side effects have been reported, in some cases serious and systemic, resulting in the revision of warning labels.
It is marketed by MEDA AB, Graceway Pharmaceuticals and iNova Pharmaceuticals under the trade names Aldara and Zyclara, and by Mochida as Beselna. Generic Imiquimod is also available as Imiquad Cream manufactured by Glenmark Pharmaceuticals Ltd. (Gracewell) India.

Side Effects of Imiquimod Cream

Below are stated in brief the Side effects of Imiquimod Cream. Nonspecific inflammation and dermatitis can occur during use of Imiquimod Cream for genital warts and molluscum. This often occurs where the skin is traumatized from scratching, or between skin folds. Blisters, bloody dry eschar, pain and discomfort often follows the use of imiquimod for skin cancers and precancerous growths.
During the treatment of large superficial basal cell carcinoma or squamous cell cancer in situ, areas of black dried crust often form. Many individuals with extensive actinic keratosis cannot tolerate the resulting reaction either. Fortunately, after completion of the therapy, the skin often heals with barely any scarring.
Other side effects include headaches, back pain, muscle aches, tiredness, flu-like symptoms, swollen lymph nodes, diarrhea, and fungal infections.

Imiquimod Cream - Dosage

Adults (12 years and over): Imiquimod Cream (Aldara or Imiquad Cream) should be applied 2 times per week for a full 16 weeks to a defined treatment area on the face or scalp.
For a typical treatment Imiquad Cream should be applied 2 times per week for a full 16 weeks to a defined treatment area. The treatment area is defined as one contiguous area of approximately 25 cm2 (e.g., 5 cm x 5 cm)

Overdosage and Overdose Symptoms of Imiquad Cream (Generic Aldara Cream)

Topical overdosing of Imiquad Cream could result in an increased incidence of severe local skin reactions and may increase the risk for systemic reactions.
The most clinically serious adverse event reported following multiple oral imiquimod doses of >200 mg (Which is equivalent to imiquimod content of >16 packets) was hypotension, which resolved following oral or intravenous fluid administration.

Imiquimod Cream (Aldara Cream) - Availability And Packaging

Imiquimod Cream is available as Imiquad Cream (Generic Aldara) which is packaged in single-use packets, with usually 12 or 24 packets supplied per box.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Imiquimod and is reproduced here under the Creative Commons Attribution-ShareAlike License