Indomethacin (Generic Indocin) - Product information and Uses

Indomethacin is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms. It is marketed under many trade names, including Indocin, Indocid, Indochron E-R, Indocap and Indocin-SR.
Indomethacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The drug is more potent than aspirin, but is not a better analgesic. The medication is best used as an anti-inflammatory, rather than an analgesic. Indometacin is used to treat the following indications ankylosing spondylitis, arthritic gout, Bartter syndrome, bursitis, cryoglobulinemia, dysmenorrhea (menstrual cramps), Exertion headaches,fever and pain associated with malignant diseases (tumors, bony metastases, lymphogranulomatosis), juvenile arthritis, nephrogenic diabetes insipidus (prostaglandin inhibits vasopressin's action in the kidney), osteoarthritis, Paget's disease of bone, paroxysmal hemicrania, hemicrania continua and migraine, Patent ductus arteriosus, pericarditis, pseudogout, psoriatic arthritis, Reactive arthritis (ReA), renal colic (pain due to kidney stones), retinopathy of prematurity, rheumatoid arthritis and tendinitis. Indomethacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus.

Indomethacin (Generic Indocin) - Availability And Packaging

Indomethacin is available as Generic Indocin Capsules which is packaged in 25 mg and 75 mg.

Side Effects of Indomethacin (Generic Indocin)

Indomethacin, therefore, like other non-selective COX inhibitors can cause peptic ulcers. Other common gastrointestinal complaints, including dyspepsia, heartburn and mild diarrhea are less serious and rarely require discontinuation of indomethacin.
Indomethacin also reduces plasma renin activity and aldosterone levels, and increases sodium and potassium retention. It also enhances the effects of vasopressin. Together these may lead to edema (swelling due to fluid retention), hyperkalemia (high potassium levels), hypernatremia (high sodium levels) and hypertension.
Generic Indocin may also cause elevations of serum creatinine and more serious renal damage such as acute renal failure, chronic nephritis and nephrotic syndrome. These conditions also often begin with edema and hyperkalemia.

Indomethacin (Generic Indocin) - Dosage

Indomethacin is always prescribed at the lowest dosage needed to achieve a therapeutic effect, usually between 50–200 mg/day. It should always be taken with food.

Overdosage and Overdose Symptoms of Indomethacin (Generic Indocin)

Indomethacin has a high acute toxicity for humans. Exact human data does not exist, but some fatal human cases, particularly in children and adolescents, have been seen.
Generally, overdose in humans causes drowsiness, dizziness, severe headache, mental confusion, paresthesia, numbness of limbs, nausea and vomiting. Severe gastrointestinal bleeding is also possible. Cerebral edema, and cardiac arrest with fatal outcome have been seen in children.
The treatment is symptomatic and largely the same as with diclofenac. However, the possibility of severe GI tract symptoms should be particularly noted.
The risk of overdose after exaggerated local treatment with gel or spray is very limited.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Indometacin and is reproduced here under the Creative Commons Attribution-ShareAlike License