Methylprednisolone Sodium Succinate (Generic Medrol) - Product information and Uses

Methylprednisolone, a potent anti-inflammatory steroid is a synthetic glucocorticoid. Glucocorticoids are adrenocortical steroids, that are easily absorbed from the gastrointestinal tract. Methylprednisolone occurs as a white to practically white, odorless, crystalline powder. Methylprednisolone Sodium Succinate Tablets are marketed as Medrol, Solu-Medrol, Predmet and Melpred.
Methylprednisolone Tablets are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. However glucocorticoids have a wide range of other uses. Common uses include Endocrine Disorders, Rheumatic Disorders, Collagen Diseases, Dermatologic Diseases, Control of severe or incapacitating allergic conditions, Ophthalmic Diseases, Respiratory Diseases, Hematologic Disorders, Neoplastic Diseases, Edematous States, Gastrointestinal Diseases and Nervous System. It is also used as a treatment for multiple sclerosis.

Methylprednisolone (Generic Medrol) - Availability And Packaging

Generic Methylprednisolone Tablets (Predmet Tablets) are packaged in 4 mg, 8 mg and 16 mg tablets. Methylprednisolone Tablets are also available as Solu-Medrol and Melpred.

Side Effects of Methylprednisolone (Generic Medrol)

The side effects of Methylprednisolone tablets are given below:
Fluid and Electrolyte Disturbances:

  • Sodium retention
  • Congestive heart failure in susceptible patients
  • Hypertension
  • Fluid retention
  • Potassium loss
  • Hypokalemic alkalosis

Musculoskeletal :

  • Muscle weakness
  • Loss of muscle mass
  • Steroid myopathy
  • Osteoporosis
  • Tendon rupture, particularly of the Achilles tendon
  • Vertebral compression fractures
  • Aseptic necrosis of femoral and humeral heads
  • Pathologic fracture of long bones


  • Peptic ulcer with possible perforation and hemorrhage
  • Pancreatitis
  • Abdominal distention
  • Ulcerative esophagitis
  • Increases in alanine transaminase (ALT, SGPT), aspartate transaminase (AST, SGOT), and alkaline phosphatase

Dermatologic :

  • Impaired wound healing
  • Petechiae and ecchymoses
  • May suppress reactions to skin tests
  • Thin fragile skin
  • Facial erythema
  • Increased sweating


  • Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment
  • Convulsions
  • Vertigo
  • Headache

Endocrine :

  • Development of Cushingoid state
  • Suppression of growth in children
  • Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness
  • Menstrual irregularities
  • Decreased carbohydrate tolerance
  • Manifestations of latent diabetes mellitus
  • Increased requirements of insulin or oral hypoglycemic agents in diabetics


  • Posterior subcapsular cataracts
  • Increased intraocular pressure
  • Glaucoma
  • Exophthalmos


  • Negative nitrogen balance due to protein catabolism

Methylprednisolone Tablets (Generic Medrol) - Dosage

The recommended initial dosage of Methylprednisolone Tablets can vary from 4 mg to 48 mg of methylprednisolone per day depending on the specific indication being treated.
In situations of less severity lower doses will be sufficient whereas in certain patients higher initial doses of Methylprednisolone Tablets may be required. The initial dosage has to be adjusted until a suffient clinical response is obtained.

Generic Medrol - Contraindications

Generic Medrol is contraindicated in patients with Systemic fungal infections and also those with known hypersensitivity to Methylprednisolone or any inactive components present in the medication.

Overdosage and Overdose Symptoms of Methylprednisolone Tablets

There is no clinical syndrome of acute overdosage with Methylprednisolone in particular or corticosteroids in general and no specific antidote is available. The treatment is supportive and symptomatic.

Additional Information

Additional Info: Prescribing Information