Montelukast Sodium (Generic Singulair) - Product information and Uses

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.
Montelukast is used for a number of conditions including asthma, exercise induced bronchospasm, allergic rhinitis, and urticaria. It is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if they alone do not bring the desired effect. Corticosteroids reduce inflammation but have no effect on leukotrienes. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other asthma medications such as theophylline.

Montelukast Sodium - Availability And Packaging

Montelukast Sodium is available as Generic Singulair Tablets which is packaged as 5 mg and 10 mg tablets. Montelukast Sodium is available under names Singulair, Montair and Montelo-10.

Side Effects of Montelukast Sodium (Generic Singulair)

Side effects of Generic Singulair include upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis, otitis, gastrointestinal disturbances, hypersensitivity reactions, sleep disorders and increased bleeding tendency, aside from many other generic adverse reactions. Its use is associated with a higher incidence of Churg–Strauss syndrome.

Montelukast Sodium (Generic Singulair) - Dosage

The recommended dosage of Generic Singulair for various indications is
Asthma: Once daily in the evening for patients 12 months and older.
Acute prevention of EIB: 10 mg tablet at least 2 hours before exercise for patients 15 years of age and older.
Seasonal allergic rhinitis: Once daily for patients 2 years and older.
Perennial allergic rhinitis : Once daily for patients 6 months and older.
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening

Montelukast Sodium (Generic Singulair)- Contraindications

Generic Singulair is contraindicated in individuals that have a hypersensitivity to Montelukast Sodium or any inactive component of this product.

Warnings and Precautions when using Montelukast Sodium (Generic Singulair)

Generic Singulair should not be used to treat an acute asthma attack.
Inhaled corticosteroid may be reduced gradually. Do not abruptly substitute SINGULAIR for inhaled or oral corticosteroids
Patients with known aspirin sensitivity should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking Generic Singulair
Neuropsychiatric events have been reported with Generic Singulair.
Instruct patients to be alert for neuropsychiatric events. Evaluate the risks and benefits of continuing treatment with Generic Singulair if such events occur.
Systemic eosinophilia, sometimes presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, has been reported.

Additional Information

Additional Info: Prescribing Information