Mupirocin (Generic Bactroban) - Product information and Uses

Mupirocin is an antibiotic which is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B, pseudomonic acid C , and pseudomonic acid D. Mupirocin has been shown to strongly inhibit protein and RNA synthesis in Staphylococcus aureus while DNA and cell wall formation were also negatively impacted to a lesser degree.
Mupirocin is used as a topical treatment for bacterial skin infections, for example, furuncle, impetigo, open wounds, etc. It is also useful in the treatment of methicillin-resistant Staphylococcus aureus (MRSA), which is a significant cause of death in hospitalized patients having received systemic antibiotic therapy. It is suggested, however, that mupirocin cannot be used for extended periods of time, or indiscriminately, as resistance does develop, and could, if it becomes widespread, destroy mupirocin's value as a treatment for MRSA. It may also result in overgrowth of non-susceptible organisms.

Mupirocin - Availability And Packaging

Mupirocin is available as Generic Bactroban Cream which is packaged in 5 g tubes. It is also available as Centany, T-Bact and several other trade names.

Mupirocin Cream - Dosage

A small amount of Generic Bactroban Cream should be applied to the affected area 3 times daily. The affected area treated may be covered with a gauze dressing if desired.

Side Effects of Mupirocin (Generic Bactroban)

The following local side effects have occurred in connection with the use of Generic Bactroban Cream Burning, stinging, or pain in 1.5% of patients; itching in 1% of patients; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of patients

Generic Bactroban - Contraindications

This medication is contraindicated in individuals with a hypersensitivity to Mupirocin any of the inactive components present in Generic Bactroban.

Additional Information

Additional Info: Prescribing Information