Omeprazole (Generic Prilosec) - Product information and Uses

Omeprazole, one of the most widely prescribed drugs internationally, is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome.
Omeprazole is available over the counter in some countries.

Omeprazole - Availability And Packaging

Omeprazole is available as Generic Prilosec which is packaged in 20 mg and 40 mg capsules. Omeprazole is also available as tablets in strengths of 10 mg, 20 mg, 40 mg, and in some countries 80 mg.
Most oral omeprazole preparations are enteric-coated, due to the rapid degradation of the drug in the acidic conditions of the stomach. This is most commonly achieved by formulating enteric-coated granules within capsules, enteric-coated tablets, and the multiple-unit pellet system (MUPS).
Omeprazole is also available for use in injectable form (I.V.) in Europe. The injection pack is a combination pack consisting of a vial and a separate ampule of reconstituting solution. Each 10 ml clear glass vial contains a white to off-white lyophilised powder consisting of omeprazole sodium 42.6 mg equivalent to 40 mg of omeprazole.

Side Effects of Omeprazole (Generic Prilosec)

The most common side effects of omeprazole (Generic Prilosec) are headache, diarrhea, abdominal pain, nausea, dizziness, trouble awakening and sleep deprivation, although in clinical trials the incidence of these effects with omeprazole was mostly comparable to that found with placebo. Other side effects may include iron and vitamin B12 deficiency, although there is very little evidence to support this.
Proton pump inhibitors may be associated with a greater risk of fractures and Clostridium difficile-associated diarrhea. Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.
Since their introduction, proton pump inhibitors in general and omeprazole in particular have been associated with several cases of acute tubulointerstitial nephritis, an inflammation of the kidneys that often occurs as an adverse drug reaction. Proton Pump Inhibitors use has also been associated with fundic gland polyposis.

Omeprazole (Generic Prilosec) - Dosage

The dosage varies according to the symptom being treated. For the Short Term Treatment of Active Duodenal Ulcer the recommended Omeprazole Dose for adult patients is 20 mg Once daily for 4 weeks. Some patients may require an additional 4 weeks.
For H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence in adult patients Triple Therapy comprising Generic Prilosec 20 mg; Amoxicillin 1000 mg and Clarithromycin 500 mg is employed. Each drug is to be administered twice daily for 10 days.
For Gastric Ulcer the recommended dose for adult patients is 40 mg of Generic Prilosec Once daily for 4 to 8 weeks whereas for GERD the recommended dose for for adult patients 20 mg of Generic Prilosec Once daily for 4 to 8 weeks. Please consult your doctor for exact dosing instructions.

Omeprazole (Generic Prilosec) - Interactions

Omeprazole is a competitive inhibitor of the enzymes CYP2C19 and CYP2C9, and may therefore interact with drugs that depend on them for metabolism, such as diazepam, escitalopram, and warfarin. The concentrations of these drugs may increase if they are used concomitantly with omeprazole.
Clopidogrel (Plavix) is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form; inhibition of CYP2C19 blocks the activation of clopidogrel, thus reducing its effects and potentially increasing the risk of stroke or heart attack in people taking clopidogrel to prevent these events.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Omeprazole and is reproduced here under the Creative Commons Attribution-ShareAlike License