Ondansetron (Generic Zofran) - Product information and Uses

Ondansetron developed and first marketed by GlaxoSmithKline as Zofran is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic (to treat nausea and vomiting), often following chemotherapy.
Its effects are thought to be on both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors

Ondansetron (Generic Zofran) - Availability And Packaging

Ondansetron is available as Generic Zofran Tablets which is packaged in 4mg and 8mg tablets.

Side Effects of Ondansetron (Generic Zofran)

Ondansetron (Generic Zofran) is a well-tolerated medication with few side effects. Constipation, dizziness and headache are the most commonly reported side effects associated with its use.
There have been no significant drug interactions reported with this drug's use.

Ondansetron (Generic Zofran) - Dosage

Generic Zofran is administered 1–3 times daily, depending on the severity of nausea and/or vomiting. The normal oral dose for adults and children over the age of 12 is 8 mg initially, followed by a second dose of 8 mg eight hours later.
The medicine is then administered once every 12 hours, usually for not more than 2–3 days. Following oral administration, it takes about 1.5 to 2 hours to reach maximum plasma concentrations.

Additional Information

Additional Info: Prescribing Information



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