Paroxetine Hydrochloride (Paxil) - Uses, Dosage and Side Effects

Paroxetine Hydrochloride which is is an odorless, off-white powder, is an orally administered psychotropic drug. Paroxetine is an SSRI antidepressant manufactured by GlaxoSmithKline. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and generalized anxiety disorder in adults.
In adults, the efficacy of paroxetine for depression is comparable to that of older tricyclic antidepressants, with fewer side effects and lower toxicity. Each film-coated tablet contains paroxetine hydrochloride equivalent to paroxetine as follows: 10 mg (yellow, scored); 20 mg (pink, scored); 30 mg (blue) and 40 mg (green).

Side Effects of Paroxetine Hydrochloride (Paxil)

Paroxetine should not be used in combination with an Monoamine oxidase inhibitors (MAOI) including linezolid, an antibiotic which is a reversible non-selective MAOI, or within 14 days of discontinuing treatment with an MAOI, and should not be used in combination with pimozide, thioridazine, tryptophan, or warfarin.
Sexual dysfunction is a common side effect with SSRIs including Paroxetine Hydrochloride (Paxil). Specifically, side effects often include difficulty becoming aroused, lack of interest in sex, and anorgasmia (trouble achieving orgasm). Genital anesthesia, loss of or decreased response to sexual stimuli, and ejaculatory anhedonia are also possible. Although usually reversible, these sexual side effects can last for months or years after the drug has been completely withdrawn. This is known as Post SSRI Sexual Dysfunction.
Among the common adverse effects associated with paroxetine treatment of depression and listed in the prescribing information, those with the greatest difference from placebo are nausea (26% on paroxetine vs 9% on placebo), somnolence (23% vs. 9% on placebo), ejaculatory disturbance (13% vs. 0% on placebo), other male genital disorders (10% vs. 0% on placebo), asthenia (15% vs. 6% on placebo), sweating (11% vs. 2% on placebo), dizziness (13% vs. 6% on placebo), insomnia (13% vs. 6% on placebo), dry mouth (18% vs. 12% on placebo), constipation (14% vs. 9% on placebo), and tremor (8% vs. 2% on placebo). Other side effects include high blood pressure, headache, agitation, weight gain, impaired memory and paresthesia. Due to the possibility of increased risk of birth defects, pregnant women or women planning to become pregnant are recommended to consult with their physician. Discontinuing paroxetine is associated with a high risk of discontinuation or withdrawal syndrome.

Paroxetine Hydrochloride (Paxil) - Dosage

Paxil should be administered as a single daily dose with or without food, usually in the morning. The recommended initial dose is 20 mg/day for adults.
If dose changes are required they should occur at a minimum interval interval of 1 week.

Overdosage and Overdose Symptoms of Paroxetine Hydrochloride (Paxil)

The symptoms associated with paroxetine overdosage include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting, dizziness, emesis, lethargy, ataxia, tachycardia and seizures. Other notable signs and symptoms observed with overdoses involving paroxetine (alone or with other substances) include mydriasis, convulsions (including status epilepticus), ventricular dysrhythmias (including torsade de pointes), hypertension, aggressive reactions, syncope, hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic dysfunction (including hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic steatosis), serotonin syndrome, manic reactions, myoclonus, acute renal failure, and urinary retention.
Plasma, serum or blood concentrations of paroxetine may be measured to monitor therapeutic administration, confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Plasma paroxetine concentrations are generally in a range of 40-400 µg/L in persons receiving daily therapeutic doses and 200-2000 µg/L in poisoned patients.

Paroxetine Hydrochloride (Paxil) - Availability And Packaging

Paroxetine Hydrochloride is available as Generic Paxil Tablets which is packaged in 10 mg, 20 mg, 30 mg and 40 mg tablets. The Generic forms of Paxil are Pari manufactured by IPCA Laboratories Ltd. and Parotin manufactured by Cipla Ltd.. Generic Paxil is also available as Aropax, Parocen and Seroxat.

Additional Information

Additional Info: Prescribing Information

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