Quetiapine Fumarate (Generic Seroquel) - Product information and Uses

Quetiapine Fumarate is an atypical antipsychotic which is approved by the FDA for the treatment of schizophrenia, and bipolar disorder. In patients with bipolar it is used for depressive episodes, acute manic episodes associated with bipolar I disorder (as either monotherapy or adjunct therapy to lithium or valproate), and maintenance treatment of bipolar I disorder (as adjunct therapy to lithium or divalproex).
Quetiapine is sometimes used off-label, often as an augmentation agent, to treat conditions such as obsessive-compulsive disorder, post-traumatic stress disorder, restless legs syndrome, autism, alcoholism, depression and Tourette syndrome. Generic Seroquel has been used by doctors as a sedative for those with sleep disorders or anxiety disorders.

Quetiapine Fumarate (Generic Seroquel) - Availability And Packaging

Quetiapine is used to treat either schizophrenia or bipolar disorder. Quetiapine Fumarate is available as Generic Seroquel Tablets which is packaged as 25 mg, 100 mg, 200 mg and 300 mg Tablets. Quetiapine is also available as Ketipinor, Q-mind XR (Torrent Pharmaceuticals Ltd.), Seroquin (Cipla Ltd.) and Qutipin (SUN Pharmaceuticals)

Side Effects of Quetiapine Fumarate (Generic Seroquel)

The most common side-effect of Quetiapine is somnolence. Other common side effects of Generic Seroquel include sluggishness, fatigue, dry mouth, sore throat, dizziness, abdominal pain, constipation, upset stomach, orthostatic hypotension, inflammation or swelling of the sinuses or pharynx, increased appetite, and weight gain.
The sedative effects may disappear after some time on the drug, or with a change of dosage, and with possibly different, non-sedative side-effects emerging. The prolonged use of high doses (over 200 mg) of quetiapine increases the risk of the patient developing tardive dyskinesia, an incurable neurological disorder. This risk increases with the duration of Seroquel treatment so patients specially if in a high-risk category may want to consider alternate options before using Seroquel.The rare, but life-threatening, neuroleptic malignant syndrome may also result from quetiapine use.

Quetiapine Fumarate (Generic Seroquel) - Dosage

The recommended initial dose of Generic Seroquel for adult patients is 25 mg twice daily, with increases in the total daily dose of 25 mg to 50 mg divided in two or three doses on the second and third day, as tolerated, to a total dose range of 300 mg to 400 mg daily by the fourth day.
Further dosage adjustments if necessary should generally occur at intervals of not less than 2 days, as steady-state for SEROQUEL would not be achieved for approximately 1-2 days in the typical patient.

Overdosage and Overdose Symptoms of Quetiapine Fumarate (Generic Seroquel)

Most instances of acute overdosage result only in sedation, hypotension and tachycardia, but cardiac arrythmia, coma and death have occurred in adults.
Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases.

Quetiapine Fumarate (Generic Seroquel) - Widthdrawal and Withdrawal Symptoms

As a result of compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, a gradual reduction in dosage is recommended to minimise or avoid withdrawal symptoms.
Withdrawal symptoms that have been reported to occur after discontinuation of quetiapine include insomnia, nausea, emesis, lightheadedness, diaphoresis, orthostasis, tachycardia, as well as nervousness, dizziness, headache, and anxiety. The present evidence suggests that these symptoms affect a small number of susceptible individuals treated with quetiapine. Chronic and long-lasting (months) rebound insomnia symptoms can occur after discontinuation of quetiapine.

Additional Information

Additional Info: Prescribing Information



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