Rosuvastatin Calcium - Uses, Dosage and Side Effects

Rosuvastatin Calcium (marketed by AstraZeneca as Crestor) is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease.
Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. Its approximate elimination half life is 19 hours and its time to peak plasma concentration is reached in 3–5 hours following oral administration.
The effects of rosuvastatin on LDL cholesterol are dose-related. At the 10 mg dose, the average LDL cholesterol reduction was found to be 46% in one trial. Increasing the dose from 10 mg to 40 mg gave a modest additional 9% absolute reduction in LDL levels (55% below baseline levels).

Rosuvastatin Calcium - Availability And Packaging

Rosuvastatin Calcium is available as Crestor Tablets which is packaged as 5 mg, 10 mg 20 mg and 40 mg tablets for oral administration. Crestor Tablets are either dark yellow (5 mg) or pink, round, or oval (40 mg), biconvex and film-coated.

Rosuvastatin Calcium (Crestor Tablets) - Dosage

Crestor Tablets can be taken with or without food, at any time of day.The Adult Dosage of Crestor Tablets ranges from 5 mg to 40 mg once daily. 40 mg dose is to be used only for patients not reaching LDL-C goal with 20 mg.

Side Effects of Rosuvastatin Calcium (Crestor Tablets)

Most common side effects of Crestor are headache, myalgia, abdominal pain, asthenia, and nausea.
As with all statins, there is a concern of rhabdomyolysis, a severe undesired side-effect.

Additional Information

Additional Info: Prescribing Information



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Rosuvastatin and is reproduced here under the Creative Commons Attribution-ShareAlike License