Vardenafil - Use, Side Effects, Dosage and Interactions

Vardenafil (INN) is a PDE5 inhibitor used for treating impotence (erectile dysfunction) that is sold by Bayer Pharmaceuticals, GSK, and SP under the trade name Levitra.

Clinical Use Of Vardenafil (Levitra)

Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors.It is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). Structurally, the difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group.
Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

Vardenafil Side Effects - Adverse Drug Reactions

The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side effect is nausea; the infrequent side effects are: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism.
One possibly serious, but rare, side effect with vardenafil is heart attack. Also in rare cases, vardenafil use may damage penile tissue, resulting in permanent impotence. The U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of Vardenafil, and other PDE5 inhibitors.

Vardenafil Dosage

Vardenafil in the form of Levitra Tablets is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil).
Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day.

Drug interactions

Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).



Considerable portions of the text here is from http://en.wikipedia.org/wiki/Vardenafil and is reproduced here under the Creative Commons Attribution-ShareAlike License